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Assessment of delta-9-tetrahydrocannabinol (THC) in saliva and blood after oral administration of medical cannabis with respect to its effect on driving abilities - Trojan V, Landa L, Hrib R, Jurica J, Rychlickova J, Zvonicek V, Halamkova L, Halamek J, Demlova R, Belaskova S, Sliva J.

Medical cannabis has recently been legalized in many countries, and it is currently prescribed with increasing frequency, particularly for treatment of chronic pain resistant to conventional therapy. The psychoactive substance delta-9-tetrahydrocannabinol ... (Source: SafetyLit)MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free. [...]

Injectable Gel Reduces Chronic Low Back Pain

No abstract available (Source: Lippincott's Bone and Joint Newsletter) [...]

Long COVID Experts and Advocates Say the Government Is Ignoring ‘ the Greatest Mass-Disabling Event in Human History ’

Dr. Ezekiel Emanuel is used to feeling like the only person in the country who still cares about COVID-19. He ignores the side-eye he gets for wearing an N95 mask at parties—a self-imposed policy that makes him “look odd” but kept him safe after a recent work dinner turned into a superspreader event. The oncologist, bioethicist, and professor at the University of Pennsylvania provides each of his students with an N95 and runs four HEPA air filters during lectures. He rolls down the windows when he gets in an Uber and goes hungry on planes so he can wear his… [...]

European Commission approves Roche ’s Vabysmo, the first bispecific antibody for the eye, for two leading causes of vision loss

Phase III data that showed people with nAMD and DME treated with Vabysmo up to every four months achieved similar outcomes compared to receiving treatment every two months with afliberceptIn addition, patients treated with Vabysmo received up to 33% fewer median number of injections compared to afliberceptReducing the number of eye injections over time could offer a less burdensome treatment schedule for individuals, their caregivers and healthcare systemsVabysmo simultaneously targets and inhibits two disease pathways involving Ang-2 and VEGF-A linked to a number of vision-threatening retinal conditionsBasel, 19 September 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that… [...]

Medical Cannabis Tied to Higher Risk for New Heart Rhythm Disorders

WEDNESDAY, Sept. 14, 2022 -- People with chronic pain who use medical cannabis have a higher risk for heart rhythm disorders versus nonusers, according to a study presented at the European Society of Cardiology Congress 2022, held from Aug. 26 to 29... (Source: Drugs.com - Pharma News)MedWorm Message: [...]

How to live without chronic back pain, according to an expert

Living with chronic back pain is not normal, nor is it necessary. This final article in a four-part back pain series by fitness expert Dana Santas empowers you to create a strategy for maintaining health and an active, pain-free lifestyle. (Source: CNN.com - Health) [...]

A fitness expert shares a game plan for living without back pain

Too often, after fruitless searches for a single magic bullet to eradicate chronic back pain, people decide that living with discomfort is a normal fact of life. But living with back pain is not normal, nor is it necessary. This last installment in our back pain series will empower you to create your own, personalized long-term strategy for maintaining back health and living an active, pain-free lifestyle. (Source: CNN.com - Health) [...]

Texas Physicians Offer Solutions to Address Increasing Overdose Deaths

As an alarming number of Texans die from overdosing on illicit opioids laced with fentanyl, physicians advise lawmakers to consider new approaches to tackle the problem. These include easing barriers to medical treatment for patients suffering from chronic pain, improving access to the overdose-countering drug naloxone, and legalizing fentanyl test strips. (Source: TMA News Room) [...]

A New Way of Thinking About Pains A New Way of Thinking About Pains

In this commentary, the author proposes abandoning the traditional temporal construct of acute pain vs. chronic pain in favor of a more patient-centric approach.Pain (Source: Medscape Today Headlines) [...]

Post-mortem oxycodone blood concentrations of hospitalized cancer and surgery patients compared with fatal poisonings - Kriikku P, Kalso E, Ojanper ä I.

In this study, all oxycodone-related medico-legal cases where death had occurred in a hospital or nursing home in Finland were investigated to determine... (Source: SafetyLit)MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free. [...]

Why You ’ re Grinding Your Teeth —And How to Stop

One morning around week six of the COVID-19 lockdown, I woke up to discover I’d gnashed a molar-sized crack down the back of my night guard, the device I wear to protect my teeth from the grinding I do in my sleep. I’d worn the acrylic barrier every night for years with minimal erosion, but suddenly I’d gnawed right through it. Like many Americans who have spent the last few years wondering where the stress and fear building up in their bodies could possibly go, the answer turned out to be my mouth. Since 2020, dentists and other oral health… [...]

You Can Still Get Long COVID If You ’ re Vaccinated and Boosted

COVID-19 vaccines were designed primarily to prevent severe disease and death—two purposes for which they continue to work very well. But when the shots first rolled out, many people also hoped they would block or even reverse symptoms of Long COVID, such as fatigue, cognitive dysfunction, chronic pain, and neurological issues. By now, it’s clear that even people who are fully vaccinated and boosted can get Long COVID, and recent research suggests that vaccines aren’t the Long COVID shields people wished for. Studies have come to very different estimates about the degree of protection vaccines offer against Long COVID. But… [...]

Preoperative Frailty and Chronic Pain After Cardiac Surgery Preoperative Frailty and Chronic Pain After Cardiac Surgery

What impact does frailty have on chronic pain following cardiac surgery in older adults?BMC Anesthesiology (Source: Medscape General Surgery Headlines) [...]

Multidimensional pain phenotypes after traumatic brain injury - Robayo LE, Govind V, Vastano R, Felix ER, Fleming L, Cherup NP, Widerstr öm-Noga E.

More than 50% of individuals develop chronic pain following traumatic brain injury (TBI). Research suggests that a significant portion of post-TBI chronic pain conditions is neuropathic in nature, yet the relationship between neuropathic pain, psychologica... (Source: SafetyLit) [...]

What Causes Sudden Vision Loss?

Discussion Vision loss, whether chronic or acute, is distressing at any time for patients and families. Prompt evaluation and treatment are important as maintenance of any acuity and light or movement is considered paramount. Most vision loss is due to chronic problems and aging issues but the differential diagnosis is broad. For any age, but especially children, uncorrected refractive errors can cause problems in not only in childhood but throughout someone’s lifetime. Visual impairment for distance vision is considered mild if worse than 6/12 in meters = 20/40 in feet or 0.3 LogMAR and for moderate impairment is 6/18 meters… [...]

Recognizing medical child abuse in children presenting with chronic pain - Sherry DD, Gmuca S, Christian CW.

We report the presentation of five children seeking treatment for chronic pain who we identified as victims of MCA. The index case had essentially not ea... (Source: SafetyLit) [...]

Final Analysis of Phase 2 GRIFFIN Study Presented for DARZALEX ® (daratumumab)-based Investigational Quadruplet Regimen in Patients with Newly Diagnosed, Transplant-Eligible Multiple Myeloma

LOS ANGELES, August 27, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the final results from the randomized Phase 2 GRIFFIN study evaluating the investigational use of DARZALEX® (daratumumab) in combination with lenalidomide (Revlimid®), bortezomib (VELCADE®) and dexamethasone (DARZALEX®-RVd), followed by maintenance therapy with DARZALEX®-lenalidomide (R), compared to RVd followed by maintenance therapy with R alone, in patients with newly diagnosed, transplant-eligible multiple myeloma. Data were presented in the plenary session at the 19th International Myeloma Society (IMS) Annual Meeting.In the primary analysis (median follow-up of 13.5 months), the GRIFFIN study met its primary endpoint, resulting… [...]

Cannabis for Pain Linked to Slight Risk for Arrhythmia Cannabis for Pain Linked to Slight Risk for Arrhythmia

Results of a case-control study showed a small increase in various arrhythmias in chronic pain patients given a medical cannabis prescription, although the absolute risk was small.Medscape Medical News (Source: Medscape Psychiatry Headlines) [...]

U.S. FDA Approves IMBRUVICA ® (ibrutinib) as First and Only BTKi Treatment for Pediatric Patients with Chronic Graft-Versus-Host Disease

August 24, 2022 (HORSHAM, PA) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved IMBRUVICA® (ibrutinib) for the treatment of pediatric patients one year and older with chronic graft-versus-host disease (cGVHD) after failure of one or more lines of systemic therapy. This milestone marks the first pediatric indication for IMBRUVICA® and the introduction of a new oral suspension formulation for patients ages one to less than 12. IMBRUVICA® is now the first FDA-approved therapy for these younger patients who previously had no approved treatment options for this life-threatening… [...]

A Rarely Discussed “Treatment” for Chronic Pain Stoked Death Rates During the Pandemic

No abstract available (Source: Lippincott's Bone and Joint Newsletter)MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free. [...]